Research Deep‑Dive

Synthetic Biology Platforms

Programming biology like code.

We design, build, and test genetic circuits in microbial chassis to produce high‑value molecules, antimicrobial peptides, and biosensors — enabling rapid prototyping of biological solutions.

Our Platform ← Back to Research
🧬
10+
Functional genetic circuits built
3
Chassis organisms (E. coli, B. subtilis, S. cerevisiae)
6
AMPs designed and expressed
Our Approach

Design‑Build‑Test‑Learn

We use modular cloning (Golden Gate, MoClo), CRISPR‑based regulation, and automated liquid handling to accelerate the design cycle.

🧩 1. Circuit Design

Computational design of promoter‑RBS‑CDN‑terminator combinations with predicted output dynamics.

⚙️ 2. Assembly & Transformation

High‑throughput assembly into modular vectors and transformation into competent chassis cells.

📊 3. Phenotypic Characterisation

Flow cytometry, plate‑reader assays, and LC‑MS for product quantification and circuit performance.

Current Highlights

  • ✓ Portable biosensor for arsenic detection in groundwater (field‑tested).
  • ✓ High‑yield production of a novel lasso peptide with antibacterial activity.
  • ✓ Orthogonal T7‑based expression system for toxic protein biosynthesis.
Associated Research Outputs
01
Modular design of a riboswitch‑based biosensor for heavy metals — Published in ACS Synthetic Biology (2025)
02
CRISPR‑dCas9 mediated tunable expression of antimicrobial peptides — Manuscript in revision
03
Metabolic flux redirection for enhanced precursor supply in E. coli — Internal white paper